James T. Arnone, Ph.D.

  • Associate Professor Biological and Environmental Sciences

Contact

office
(315) 445-4792
email
arnonejt@lemoyne.edu

Location

Science Center 215

My research group explores two broad areas of study: gene expression – the many regulatory mechanisms that underlie this process – and the molecular underpinnings of the aging process. Our model system is the model eukaryote, Saccharomyces cerevisiae (commonly known as baker’s or brewer’s yeast). Of interest are questions that include: how does the cell coordinately express large sets of genes to adapt to its niche and maintain homeostasis and survival? How does the breakdown of cellular processes – such as nuclear morphology or mitochondrial function alter and affect lifespan?

Students in my lab use a combination of genetics, computational and bioinformatic approaches, as well as a diverse repertoire of molecular biological approaches and techniques to answer these questions and more! If you have an interest in learning more about my research – or have a desire to work on a project in my lab – reach out to me by email anytime!

Education

  • Ph.D., Molecular Biology and Biochemistry, Wesleyan University
  • M.A., Biomolecular Sciences, Central Connecticut State University
  • B.S., Molecular and Cell Biology, the University of Connecticut

Areas of Specialization

  • Gene Expression
  • Genetics
  • Genomics
  • Aging

Awards and Honors

  • Intramural Research Training Award (IRTA) Post-Doctoral Fellow, National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health
  • Mentor: American Society for Microbiology Future Leaders Mentorship Fellowship (FLMF), 2024-2026
  • Topical Advisory Panel Member: International Journal of Molecular Sciences (IJMS), 2023-Present

Publications

  • Cittadino, G.M., Andrews, J., Purewal, H., Estanislao, P. A. A., Arnone, J. T. (2023) “Functional clustering of metabolically related genes is conserved across Dikarya” (Journal of Fungi, 9(5),523).
  • Odoh, C. K., Kamal, R., Xue, H., Lyu, L., Arnone, J. T., & Zhao, Z. K. (2023) “Glucosylglycerol Extends Chronological Lifespan of the Budding Yeast via an Increased Osmolarity Response” Indian Journal of Microbiology, 1-8.
  • Asfare, S., Eldabagh, R., Siddiqui, K., Patel, B., Kaba, D., Mullane, J., Siddiqui, U., Foley, J.J., IV, and Arnone, J.T. (2021) “Systematic Analysis of Functionally-Related Gene Clusters in the Opportunistic Pathogen, Candida albicans”, Microorganisms, 9(2), 276.
  • Hagee, D., Abu Hardan, A., Botero, J.M., and Arnone, J.T. (2020) “The Role of Genomic Clustering of Functionally Related Gene Families in Ascomycota Fungi”, Computational and Structural Biotechnology Journal. 18, 3267-3277.
  • Cera, A., Holganza, M.K., Abu Hardan, A., Gamarra, I., Eldabagh, R.S., Deschaine, M., Elkamhawy, S., Sisso, E.M., Foley, J.J., IV, Arnone, J.T. (2019). Functionally Related Genes Cluster into Genomic Regions That Coordinate Transcription at a Distance in Saccharomyces cerevisiae. mSphere 4:e00063-19.